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To our knowledge, this is the first randomized, placebo controlled study for the safety and efficacy of SB and SPA treatments of hyperammonemia

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Common Side Effects water retention or puffiness increased appetite fatigue or daytime sleepiness headaches nausea or dizziness redness or irritation at the injection site These effects are usually manageable and often improve as the body adjusts or as dosing is refined under medical supervision

Nevertheless, these studies collectively suggest potential benefits of lipoic acid for chemotherapy-induced neuropathy at daily doses ranging from 600 mg to 1,800 mg, though the larger trial underscores the need for well-designed regimens and careful patient adherence to confirm efficacy over extended treatment courses

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