Unlike earlier GH secretagogues, ipamorelin exhibits high selectivity, minimal activity at other hormonal axes (ACTH, cortisol, or prolactin), and potent GH release in both animals and humans
Therapy for unhealed gastrocutaneous fistulas in rats as a model for analogous healing of persistent skin wounds and persistent gastric ulcers: stable gastric pentadecapeptide BPC 157, atropine, ranitidine, and omeprazole
To get it into a swallowable tablet, Novo Nordisk pairs the drug with an absorption helper called SNAC (sodium N-(8-(2-hydroxybenzoyl)amino)caprylate)
Subsequent studies demonstrated that centrally administered GLP-1 also induces an aversive response and activates sympathetic nervous system pathways, potentially indirectly controlling brown adipose tissue thermogenesis (8)
Diabetes Obes Metab 22:938946