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Women with polycystic ovary syndrome (PCOS) who, in addition to obesity, often have insulin resistance with impaired ovulation and difficulty in getting pregnant, may particularly benefit from this type of treatment

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"If you go off treatment, likely the weight returns, and so that prolonged treatment is important," he said

While these findings support the expanding role of GLP-1RAs beyond glycemic and cardiometabolic control, the authors caution that randomized trials are needed to establish a causal relationship and assess long-term safety for neuroprotective outcomes