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Severe vitamin B12 deficiency affects about 3 percent of adults in developed countries, but a more marginal deficiency may impact 26 percent, with the highest rates among adults older than 60

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When Shh binds to the Ptc-1 receptor, inhibition of Smo is relieved, thereby activating Gli transcription factors and allowing Gli proteins to translocate from the cytoplasm into the nucleus, further mediating the downstream effects of the Shh signaling pathway [41]

2014): Benoist CC, Kawas LH, Zhu M, et al