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Revised Date: January 18, 2023 Recommendations and Topics Scope Key Recommendations Background Epidemiology Patient Risk Factors Associated with B 12 Deficiency Patient Risk Factors Associated with Folate Deficiency Prevention Diagnosis Management Ongoing Care References Resources Appendix A: Dietary sources of cobalamin Scope This guideline covers the primary care investigation and management of cobalamin (vitamin B 12 or simply B 12 ) and folate deficiency in adults

2, 3 Recent studies have implicated abnormalities in systemic physiology that transcend organ specific dysfunction, at least in some children with ASD

Glutathione blocks the production of most inflammatory cytokines in the body, detoxifies the liver and protects cells from free radicals, which are at the root of many diseases

An SOD-mimetic agent, TEMPOL, is currently in clinical trials for radioprotection and to prevent radiation-induced dermatitis