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Treatment of DAN DAN is a serious complication of diabetes mellitus that affects the ANS, leading to dysfunction in multiple organ systems

Diabetes Therapy 13(9):16211634 Maya-Vetencourt JF (2013) Activity-Dependent NPAS4 Expression and the Regulation of Gene Programs Underlying Plasticity in the Central Nervous System

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Furthermore, lifestyle factors such as poor posture, which can strain the jaw and neck muscles, may also contribute to the discomfort experienced during chewing

A deficiency of bisphosphoglycerate mutase results in a marked decrease in red cell 2,3-BPG levels