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( d ) Predicted lumiflavin binding site modelled into the structure of the NS5B primed initiation complex (PDB:4WTM) colored by subdomains: fingers (pink), palm (light blue), thumb (pale green) and beta-loop (yellow)

Primary dysmenorrhea causes mild cramps to severe abdominal pain with fatigue, nausea, and headaches, typically without pelvic pathology, while secondary cases accompany conditions like endometriosis, uterine fibroids, or pelvic inflammatory disease