Even with cost as a consideration for some, a dramatic uptick in demand has produced recent shortages, creating barriers for others needing these medicines
In October 2025, it became Indias top-selling drug as its monthly sales crossed Rs 100 crore and surpassed Augmentin, a widely used antibiotic that typically ranks 1 on the drugs' sales chart most time of the year
[DOI] [PubMed] [Google Scholar] 28.Watanabe S., Ajisaka R., Masuoka T., Yamanouchi T., Saitou T., Toyama M., Takeyasu N., Sakamoto K., Sugishita Y
The 1858 C/T SNP of the PTPN22 gene is a risk factor for HT because it causes an arginine-tryptophan substitution at codon 620 (R620W), because decreased T cell signaling may results in poorer thymic elimination of autoreactive T cells, or an increased function of PTPN22 may lead to a decrease in regulatory T cells (Tregs) responsible for preventing autoimmunity
It also exhibits analgesic and anti-inflammatory properties, accelerating the healing of sprains, tears, and tissue damage by increasing blood flow to injured areas