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Key Differences and Commonalities Despite geographical and organisational differences, several common themes emerge across guidelines

Methylcobalamin (methyl B12) is a cofactor for the enzyme methionine synthase , which converts homocysteine to methionine

It can take many years (approx 20) to develop a deficiency disease in those altering their diet to one lacking in B12 due to reabsorbtion however, if failure to absorb leads to B12 deficiency disease occur within a few years (3-4)