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Because it targets more receptors, retatrutide may also offer broader metabolic benefits, though side effects can be slightly more noticeable early on

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Metabolism Based on an oral 14C-orlistat mass balance study in obese patients, two metabolites, M1 ((the hydrolyzed -lactone ring product of orlistat) and M3 (sequential metabolite after M1's cleavage of the N-formyl leucine side-chain), accounted for approximately 42% of total radioactivity in plasma

doi: 10.1002/art.37853 71 GaoBCalhounKFangD