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Injection site reactions vary across the GLP-1 receptor agonist class based on formulation characteristics, injection frequency, and dosing volumes

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These structural alterations in regions relevant to mood regulation suggest a neuroanatomical link between T2DM and depression

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Dosing: Three times daily with meals Must take with or within 1 hour of meals containing fat Cost: Prescription (Xenical 120 mg): $100-$200/month OTC (Alli 60 mg): $40-$60/month Who Should Consider: Very few patients benefit May be option if all other medications contraindicated Extremely motivated to follow low-fat diet Dont mind frequent GI side effects Most weight loss specialists dont recommend orlistat due to poor effectiveness and troublesome side effects