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Rapid weight loss increases gallstone risk regardless of the method

The manufacturer (Novo Nordisk) specifies that unopened pens must be refrigerated, while in-use pens may be kept at room temperature (not exceeding 30C) for up to 6 weeks

Most insurance companies do not cover the cost of oral semaglutide for weight loss

A 2025 Bayesian network meta-analysis reported that 10.6% of patients experienced diarrhea while using semaglutide, according to Comparative gastrointestinal adverse effects of GLP-1 receptor agonists and multi-target analogs in type 2 diabetes

Weeks 5-8: For many users, this is when adaptation begins