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Elevated intracranial pressure is a recognized migraine aggravating factor, and weight loss reliably reduces intracranial pressure

It is a widely used bioactive compound with substantial therapeutic and biological activity [155], including anti-inflammatory [246, 248], gut microbiota-regulating [139], anti-neuroinflammatory [141], and antioxidant effects[89], and is used to treat various diseases

It is dose-dependent, reversible, and generally does not impair absorption of most co-administered medications to a clinically meaningful degree" (Mayo Clinic Proceedings, 2024)

Sequence grew rapidly and was acquired by WeightWatchers in April of 2023. according to the brand representative