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The DAO enzyme is produced in the villi lining the small intestines and is released to metabolize histamine.[ref] Histamine methyltransferase (HMNT) enzyme: The HMNT enzyme works throughout the body, including in the brain, to deactivate and break down histamine created by your cells .[ref] Too much histamine can result in allergy-like symptoms, including the histamine intolerance symptoms listed above

doi:10.3233/JAD-142814 Weiss, Jessica B et al

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Catalpol exerts a neuroprotective effect in the MPTP mouse model of Parkinson's disease