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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Gupta D, Peshavaria M, Monga N, Jetton TL, Leahy JL

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The fact that it influences actin tells you a lot about why researchers treat it differently from BPC-157

Many of you also want to know, "are GLP-1 patches FDA approved?" This is a critical question