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Lamas GA, Bhatnagar A, Jones MR, et al

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GLP-1 Medications and Mental Health: Separating Fact from Fiction Key Points GLP-1 medications do not increase risk of depression, anxiety, or suicidality compared to placebo These medications modestly improve mental health-related quality of life independent of weight loss Emotional eating and food cravings significantly decrease with GLP-1 treatment Psychiatrists should proactively prevent weight gain from psychiatric medications, not just accept it as inevitable GLP-1s may be particularly useful for antipsychotic-induced weight gain, similar to how we already use metformin Side effects are mostly gastrointestinal and manageable with proper dosing and titration Theres been a lot of noise about GLP-1 medications and mental health

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Because of the increased requirements applicable to these types of studies, it is critical that companies conducting these studies carefully structure their drug development programs to ensure that all studies are appropriately capturing the level of detail and thoroughness which FDA will require when reviewing an NDA

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EMEA-003258-PIP02-23 Paediatric investigation plan for retatrutide

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