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High costs, lack of insurance coverage, and adverse effects contribute to discontinuation, especially among younger and low-income users

Plasma was collected post-euthanasia, stored at 80C, and analysed for insulin and GCG levels by ELISA

No painful injections to prepare

The observations of the present study and previous safety evaluation and pharmacodynamic research will provide basic information for further comprehensive clinical research

Participants taking oral semaglutide experienced clinically meaningful weight loss, with average reductions exceeding 16% when paired with diet and exercise, and substantial weight loss even without intensive lifestyle modification