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In my practice, I often have to decide: do we go straight to supplementing glutathione, or do we support the body in making its own by using NAC

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40,41 Initially advocated to NAGS deficiency, its safety, its quick action, and its oral administration incite some authors to propose its use in neonates as soon as they are diagnosed with severe hyperammonemia even before diagnosis confirmation

Because these factors often occur together, plateaus are best evaluated with a comprehensive, medically guided approach rather than a single change

BMJ Open 2020, 10: e035645