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Your provider's decision to escalate beyond this dose depends on tolerability, efficacy response, and individual clinical goals

Clinical evidence SELECT cardiovascular outcomes SELECT enrolled 17,604 adults aged 45 years with established atherosclerotic cardiovascular disease (prior MI, stroke, or symptomatic peripheral arterial disease) and BMI 27 kg/m, but without diabetes, randomizing them 1:1 to semaglutide 2.4 mg SC weekly (after titration) or placebo on top of standard CV therapies

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Compounded semaglutide at $179-299 per month is the cheapest option with comparable effectiveness to tirzepatide