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At the day 100 of the differentiation of AD organoids, its essential to highlight that the pathology became advanced, potentially leading to severe cell damage due to increase in pathology and the presence of apoptotic bodies

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Figure 6 Having demonstrated that metformin treatment significantly inhibits oxidative phosphorylation in both in vitro and ex vivo models of rectal cancer, the effect of metformin on histologically-confirmed normal rectal tissue biopsies ( n =12, median age of 41.5 y) taken from non-cancer patients was assessed in real-time using the Seahorse XFe analyser

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GLP-1R is widely distributed in tissues such as the islets of Langerhans, brain, heart, kidneys, and gastrointestinal tract