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Clinical eligibility follows FDA labeling for Wegovy and Zepbound: BMI 30+ or BMI 27+ with at least one weight-related comorbidity such as type 2 diabetes, hypertension, dyslipidemia, OSA, or cardiovascular disease

Findings in JAM-A-deficient mice further establish an important role for JAM-A for the intestinal barrier

The primary safety considerations involve thyroid function monitoring, awareness of potential medication interactions, and recognition of symptoms requiring medical attention