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These selectivity studies documented that the Aib substitution is the critical structural determinant of Ipamorelins selectivity, eliminating hypothalamic CRH co-stimulation while preserving full somatotroph GHS-R1a engagement establishing Ipamorelin as the reference selective GHRP against which the HPA axis co-stimulation profiles of other GHRPs are benchmarked

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Shakib P, Kalani H, Ho J, Dolatshah M, Amiri S, Cheraghipour K