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Similarly, in an earlier study, the up-regulation of iNOS in the intestinal epithelial cells (IECs) has been closely associated with the initiation and maintenance of intestinal inflammation in IBD, which can be potentially used as a non-invasive blood-based biomarker of IBD, as documented (139)

Moreover, the link between intestinal dysbiosis and HCC has been well established

Kleber, H.P

Kosiborod MN, Esterline R, Furtado RHM, Oscarsson J, Gasparyan SB, Koch GG, Martinez F, Mukhtar O, Verma S, Chopra V, Buenconsejo J, Langkilde AM, Ambery P, Tang F, Gosch K, Windsor SL, Akin EE, Soares RVP, Moia DDF, Aboudara M, Hoffmann Filho CR, Feitosa ADM, Fonseca A, Garla V, Gordon RA, Javaheri A, Jaeger CP, Leaes PE, Nassif M, Pursley M, Silveira FS, Barroso WKS, Lazcano Soto JR, Nigro Maia L, Berwanger O

Polyphenols: Immunonutrients tipping the balance of immunometabolism in chronic diseases