These alterations change the hypothalamic neuropeptide expression: the expression of CA-AMPK enhances the effect of fasting, increasing the expression of NPY and AgRP in the ARC and the melanin-concentrating hormone in the lateral hypothalamus, whereas the hypothalamic expression of DN-AMPK decreases the expression of orexigenic neuropeptides NPY and AgRP in ARC [88, 118]
Scientific Evidence: A study found that higher intake of omega-3 fatty acids improved insulin sensitivity and reduced inflammation in patients on GLP-1 therapy
For practitioners treating GLP-1 non-responders, this evidence suggests a paradigm shift in intervention timing
Mir Ali, MD, is a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California
Current evidence on KD and the skin remains limited, focusing mainly on inflammatory skin diseases such as acne, psoriasis, and hidradenitis suppurativa (HS), as well as cutaneous melanoma