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Immunoreactivity of urate transporters, GLUT9 and URAT1, is located in epithelial cells of the choroid plexus of human brains

*Med Sci Monit.* 12(1):BR36-45

However in our opinion, the low probability of MS coincidence with another rare disease, together with the animal studies where MS is never a consideration, makes it more likely that these human examples align with an inside-out model (Figure 2), where a primary biochemical derangement of myelin, coupled with an immune predisposition, culminated in a MS-like phenotype

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The result is that improvements in gut symptom burden, mucosal integrity, and post-meal function often begin within the first 7 to 14 days of the protocol