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Using this strategy, we were able to identify three chemically distinct GLP-1R agonist candidates from large compound libraries: GQB47810 (non-peptidic small molecule), DPDPE (an endorphin-derived peptide), and neuromedin C, demonstrating the ability of the pipeline to capture diverse activation strategies and efficiently guide experimental validation

Science 324 , 651654 (2009)

T.OlefskyJ

Those with high antibody levels in cocaine vaccine trials did show reduced cocaine use and less subjective high, but the proportion who achieved this was too low for regulatory approval