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In mice fed Se deficient diets, testicular atrophy, reduced diameter of the seminiferous tubules, osseous metaplasia, and reduced spermatogenic activity were observed: no mitotic activity in spermatogonia, reduced the number of spermatogenic cell lines (including stem cells, pachytene spermatocytes, spermatids, and maturing sperms), and higher rates of abnormal morphology of sperm were found without difference in chromosomal abnormalities in spermatocytes (85, 100)

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The development of a similar small molecule, lotiglipron, was unceremoniously halted due to liver toxicity concerns

Robinson LE, Holt TA, Rees K, Randeva HS, O'Hare JP