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Blood samples were collected from participants on days 7, 14, and 21

doi: 10.1038/bjc.2015.225

Oxidative stress, which is initiated by free radicals (FR) and reactive oxygen species (ROS) promoting lipid peroxidation and oxidation of GSH to form GSSG, contributes to the reduction of this important molecule and the change in the ratio of GSH/GSSG of 100:1 to 10:1 or even 1:1 (Pastore et al

Stability is a critical concern since excessive degradation may lead to subtherapeutic dosages, which can potentiate the selection of resistant pathogenic strains in the long term, therefore leading to treatment failure and economic loss (12, 25, 26)

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