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Apart from its main substrate H 2 O 2 , the CAT enzyme could also process other oxidative species such as O 2 - , OH, 1 O 2 , hypochlorous acid (HOCl), NO, and peroxynitrite (ONOO - )

p=0.004), a finding corroborated by the SUSTAIN-6 trial

Because these medications slow down digestion, constipation is a primary side effect with GLP-1s (2)

For the last 50 years, bariatric surgery has been the most effective treatment for obesity resulting in approximately 25% weight loss, whilst also improving the control of type 2 diabetes mellitus (T2DM) and reducing cardiovascular and cancer deaths

Genetic predispositions in inflammatory pathway genes may also modulate baseline gastrointestinal vulnerability