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It notes that women in perimenopause or menopause may respond differently to GLP-1 therapy than premenopausal peers, because estrogen-mediated changes affect appetite and glucose regulation

Preliminary findings point to possible contributions to astrocyte functioning and the regulation of brain-derived neurotrophic factor (BDNF), a molecule central to neuronal stability and neurogenesis

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Moore-Vogel explains: Using non-standard doses requires additional regulatory steps , delaying the trial