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The various chemicals that induce liver enlargement associated with enzyme induction are presumed to be stimulating a hepatic physiological adaptation to an increased workload demand

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Ethics approval and consent to participate This review synthesizes previously published scientific studies and does not include any experiments involving human subjects, animals, or the acquisition of new clinical information

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Therefore, CB-839 has been tested in many clinical trials, including colorectal cancer (NCT02861300), triple-negative breast cancer (NCT02071862), renal cell carcinoma (NCT03163667), melanoma (NCT02771626), and others (Table 2)