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Food and Drug Administration first approved Trulicity as a treatment for Type 2 diabetes

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The only downside was how difficult it was to tear open, but this ensures the product stays sealed and sterile until use

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When cysteine residues in KEAP1 undergo redox oxidation, NRF2 interacts with the Cul3/RING-box protein complex, ultimately leading to NRF2 ubiquitination and subsequent degradation via proteasomes

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