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Another potential source of ROS in human spermatozoa is a trans-plasma membrane oxidoreductase system that removes electrons from NAD(P)H on the cytoplasmic surface of the cell and transfers them to oxygen on the outer leaf of the plasma membrane via intermediate carriers such as ubiquinone

Br J Cancer (2022) 126(12):168494

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References 1 Growth Hormone & IGF ResearchLong-Arg3-IGF-1: structure, reduced IGF binding-protein affinity, and extended biological activity of the analog