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Chavez-Tapia NC, Cesar-Arce A, Barrientos-Gutirrez T, et al

It was only recognized in the late 1980s that desensitization of insulin secretion, which describes a state of decreased secretory responsiveness of -cell to the glucose stimuli, is a pathophysiological phenomenon of -cell function and not just an in vitro artifact 30

We also measured intracellular GSH concentrations, reactive oxygen metabolites, and lipid peroxides

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Stewart OA, Wu F, Chen Y