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In addition to peripheral effects, certain hepatokines, such as FGF-21, SELENOP, Fetuin-A, ANGPTL3, MANF, Adropin, ApoJ, and SHBG, exhibit direct or indirect effects on the CNS and represent promising therapeutic targets for AD (Figure.2)

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The tradeoff is larger injection volumes at higher doses

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Sermorelin is often considered a gentler alternative to CJC-1295 with ipamorelin, with a shorter duration of action that more closely mimics natural GHRH release patterns