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A randomized, double-blinded, placebo-controlled phase IIa preliminary clinical study (NCT01755858) was carried out on 14 patients with severe atherosclerotic renal artery stenosis who required PTRA for severe hypertension and/or decreased renal function

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however, in the case of injury or disease, loss of NMNAT activity leads to NAD + depletion and NMN accumulation, which in turn activates SARM1 53,54,289

DOI: 10.5923/j.env.20120203.05 51