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The elevated SOD2 activity is achieved as a result of an upregulation of sirtuin 3 (SIRT3), one member of a family of epigenetic enzymes located primarily in the mitochondrial matrix that regulates a variety of metabolic processes (104, 105)

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Instead, the program may cover semaglutide (the generic equivalent) only if a patient has type 2 diabetes diagnosed first, or if they can demonstrate a documented medical comorbiditysuch as cardiovascular disease or severe sleep apneathat makes obesity a secondary treatment target rather than a primary one