The most common myelin disorder of the CNS is multiple sclerosis (MS), characterized by motor, sensory and cognitive impairments resulting from demyelinating lesions, considered to be initiated by transgression of immune constituents across blood-brain and cerebrospinal fluid (CSF) barriers
In mitapivat-treated 4.2 / mice, we noted decreased protein oxidation in liver as determined by Oxyblot (Figure 5C and Supplemental Figure 8B), which was accompanied by blunted activation of Nrf2 and NF-B p65 (Figure 5D and Supplemental Figure 8C) with resultant downregulation of Nrf2-related cytoprotectors such as heme-oxygenase-1 (HO-1) and Gpx1 (Figure 5E and Supplemental Figure 8D) (17, 46, 47)
Peripheral neuropathy, subacute combined degeneration of the spinal cord, or cognitive impairment indicate more advanced deficiency and generally require intensive treatment over extended periods
Animal studies have shown a suppression of autophagy in activated microglia and infiltrating macrophages following TBI (Hegdekar et al., 2023)
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