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Clinical data shows that nausea peaks during the first 2 to 4 weeks of starting semaglutide or when doses increase, with most symptoms resolving within 4 to 8 weeks as tolerance builds

It works primarily through GLP-1 receptor activation to reduce appetite and improve blood sugar regulation

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doi.org/10.1007/s13555-026-01792-0 Thamotharan N, Harikumar MV, Sundaram M, et al

First, only about 60% of participants completed the full 46-week treatment period (233 of 386 treated participants