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4 Discussion Obesity is a highly prevalent, chronic, relapsing disease requiring long-term management ( via the incretin pathway, stimulating insulin and inhibiting glucagon secretion in a glucose-dependent manner, leading to lower blood glucose levels with low risk for hypoglycaemia ( To determine the role of semaglutide in obese mice, we performed intraperitoneally injections of semaglutide to HFD-induced obese mice, whereas the NCD and HFD groups were treated with saline for 12 weeks

doi: 10.1016/j.arr.2023.102077 38 DixonS

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