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Given that treatment discontinuation and switching cannot be directly ascertained within the TriNetX platform, patients were required to have continued records of the initial treatment between 3 months and 1 year after the index date

Their efficacy varies across different substances, with inconsistent results observed in chronic alcohol use models

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Trial subjects reported improved skin hydration within 1-2 weeks, noticeable texture and firmness improvements at 4-8 weeks, and reduced fine lines with better skin resilience at 8-12+ weeks