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Lancet 393 (10184), 19581972

2.5 Discontinuation for Iodinated Contrast Imaging Procedures Discontinue XIGDUO XR at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR less than 60 mL/min/1.73 m2, in patients with a history of liver disease, alcoholism or heart failure

What research does show: Greater average weight reduction at higher doses Greater HbA1c reduction at higher doses Increased side effects with dose escalation What research does not yet establish: Whether ultra-low doses maintain meaningful long-term weight reduction Whether microdosing produces comparable metabolic outcomes Whether indefinite low-dose therapy is effective for maintenance Much of the online discussion is anecdotal rather than trial-based

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Although there is limited human data, animal studies indicate potential risks to the developing fetus