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Nonetheless, the long-term administration of GLP-1 RAs requires vigilant monitoring to minimize potential adverse effects, including gastrointestinal disturbances and pancreatic overstimulation

Cell (2015) 161(1):14660.10.1016/j.cell.2015.02.022 10 HotamisligilGSShargillNSSpiegelmanBM

He compares the current hype around these drugs to the historic discussions about fenfen, a drug combination that was later pulled from the market due to safety concerns