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Skin biopsies from subjects were obtained under a research protocol described in the Methods section

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GLP3 Research Administration Administration Routes in Research Preclinical pharmacology studies evaluated mechanisms through: In vitro receptor activation assays using transfected cell lines Ex vivo tissue studies examining receptor binding and signaling Animal models (primarily mice) to assess acute and chronic metabolic effects Common Model Systems GLP3 research has utilized multiple experimental approaches: Human Clinical Studies Phase 1b studies in healthy volunteers and adults with type 2 diabetes Phase 2 randomized controlled trials in obesity and type 2 diabetes Substudy populations including participants with MASLD Preclinical Models Mouse models: C57BL/6 obese mice for acute and chronic metabolic studies

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Prolonged Exos administration might inhibit immune surveillance and trigger autoimmune responses, increasing susceptibility to infections or malignancies