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Due to accumulation of metabolic intermediates, impaired carnitine biosynthesis, reduced protein intake, and increased removal of carnitine through hemodialysis (HD), patients who undergo routine HD usually present with plasma carnitine insufficiency [54]

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The ENS afferent fibers innervating the intestinal mucosa are derived mainly from primary intrinsic afferent neurons which form synapses with intestinal epithelial cells and EECs [7]

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These GLP-1 agonists delay gastric emptying significantly, increasing the risk of pulmonary aspiration during emergency surgeries or procedures where proper fasting isnt ensured