they are effective only when given before injury, and thereby, less likely to play the role of the endogenous cytoprotective agent in permanent maintenance of the stomach and gastrointestinal tract integrity
Shots are administered via a subcutaneous injection (under the skin)
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Although some patients develop a mild rash to allopurinol that remains mild over time, or respond to antihistamines, continuing the allopurinol despite a rash is not advised, since the rash can worsen unpredictably
A central aspect of its activity observed in research models is its profound influence on angiogenesis, the formation of new blood vessels
