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All animal experiments were performed in accordance with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the Weill Cornell Medical College Animal Care Committee or the Veterans Administration and Boston University Animal Care Committees

J Biol Chem 282: 3468434692

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[3] What Happens When Gut NAD+ Is Depleted The same research team found that obese mice fed a high-fat diet showed the same pattern: compromised intestinal NAD+ biosynthesis, impaired GLP-1 production, and disrupted postprandial glucose metabolism

ROR = 1.1, 95% CI 1.091.11) Gastrointestinal disorders (n = 33,685