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B 12r and B 12s can be prepared from cyanocobalamin by controlled potential reduction, or chemical reduction using sodium borohydride in alkaline solution, zinc in acetic acid, or by the action of thiols

34 CLINICAL FEATURES Patients generally have a long-standing history of heartburn or acid regurgitation but they can be completely asymptomatic

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This is often referred to as SSIM (subsquamous intestinal metaplasia) or buried glands

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