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GLP-1 receptor agonists are synthetic peptides that mimic endogenous GLP-1 to enhance insulin secretion, suppress glucagon, and reduce appetite

In the STEP1 trial, semaglutide (2.4 mg) induced a mean weight loss of 14.9% among overweight or obese patients who did not have T2DM [68]

Novo has since launched a broad late-stage program for CagriSema, including the Phase III trials REDEFINE 1, which is assessing its efficacy as a weight loss therapy, and REDEFINE 2, designed to include type 2 diabetes patients with excess body weight

A review of brain atrophy subtypes definition and analysis for Alzheimers disease heterogeneity studies

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