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doi: 10.3389/fcimb.2026.1752304 Received 23 November 2025 Revised 12 January 2026 Accepted 31 January 2026 Published 19 February 2026 Volume 16 - 2026 Edited by Teclegiorgis Gebremariam, Lundquist Institute for Biomedical Innovation, United States Reviewed by Fatemeh Ahangarkani, 4cyte Pathology, Australia Sanam Dolati, Lundquist Institute for Biomedical Innovation, United States Updates Copyright 2026 Wu, Jiang, Wang, Chen, Chen and Da

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Specifically, inhibiting HDAC8 can effectively reduce the cleavage of caspase-3 and polyadenosine diphosphate ribose polymerase 1 (PARP1), decrease the expression of Bax, and maintain the level of Bcl-2 in injured kidneys to reduce cell apoptosis